Sarah thanks for your response! Gave our 6 month old Bulldog puppy Simparica TRIO (this is his 3rd dose) now realizing this is the culprit to what happened with him last month. Would you mind sharing what happened with your pup? No this puppy hasnt had seizures and I came to this forum to see other problems with this medicine. I thought maybe he got into something. They must get some kind of monetary bonus for only selling Simparica. I bought chicken last night he ate some of that . He likely does not even have a seizure disorder- just a reaction to this de-wormer that I was assured over and over again was a great thing for him to take and couldn't possibly cause this! He has been eating the same organic GF food for the past several years. Started in February and within a couple of weeks ears started twitching. Im wondering if there is any correlation as we havent changed anything else with him. 10 days after taking Simparica, she started having muscle tremors. They gave him IV glucose to raise his Potassium level. However, your dog must have a history of negative test results for these diseases. . Stay safe! I not any kind of a medical doctor nor am I a vet however I do often research many topics on health related matters both canine and human for decades and then use my common sense to draw logical conclusions or make reasonable guesses. Her blood work came back fine. Pyrantel pamoate is a nematocide (kills some worms) belonging to the tetrahydropyrimidine class. Took him to the vet Potassium level was so high they did an ekg and his heart was not beating regular. Instead, it kills larvae, allowing your dog to avoid infection. Haven't noticed any other symptoms to him besides the puking, not eating and skittish. I gave my 10 year old Bull Terrier a dose of Simparico Trio Thursday December 3. We just brought him home from hospital today. Did you ever do an MRI or spinal tap? Was not too excited about it, and I really should've declined it. This class has been associated with neurologic adverse reactions including tremors, ataxia, and seizures. Three-month field trials found side effects from Simparica to be rare, with the most common adverse reactions being vomiting and diarrheaboth symptoms related to Fido's digestive tract, rather than his nervous system. If you miss a dose of Simparica Trio, give it immediately and resume monthly dosing. Moxidectin was first approved by the FDA in 1997 for the prevention of heartworm disease in dogs. Gave my 3 year old Yorkie Simparica and 24hrs later he became hyperactive panting pacing and started hiding in dark places. He is otherwise normal and healthy. What Are Potential Simparica Trio Side Effects in Dogs? And both of my other labs, basically house dogs, ended up with a droopy left eye. I called the vet and they said it was likely brought on by stress. Did you go to the vets or not? four times. It was the first time she had taken Simparica. Seizures have been reported in dogs receiving isoxazoline class drugs, even in dogs without a history of seizures. He wasnt throwing up at all until he received this medication. While veterinarians often prescribe medications for off-label uses, your veterinarian will determine whether Simparica is right for your pet. I dont like that my dog looks at me like he doesnt know who I am. My precious rescue has been sick twice, currently on her second episode. Will this ever get better as the med wears down? If there are enough reports they may have to pull it off the market until further safety tests can be done. If most side effects are mild, ( vomiting 12 hours later could be due to other things the dog has eaten within those 12 hours), I am ok with that. It is recommended that all pets be tested for existing heartworm infection prior to starting treatment with Simparica Trio. I will do anything to stop this from hurting or killing anyone else's baby. My vet never mentioned that puppies under 6months cannot be prescribed this medication. like what??? I would absolutely rather be safe than sorry.. no more simparica trio for that guy. Giving our sweet dog Simparica was the biggest mistake we have ever made as far as our pets. He never ever used to do this. Advised her to put a big note on our account that she is never to have this again. We spend last night at the Emergency Vet, and all day today at her normal vet. Our dog has had 2 Seizures this month and we are going to stop using Simparica. He was in excellent health prior to this incident. If you havent already done so, please call the simparica trio phone number and report your dogs symptoms. Poor baby has had vomiting and diarrhoea ever since. Was checking out before using . Do you have contact details that you can share with me. Are their enough people to file a class action suit? I PRAY that our baby is okay with this second dose. Now that Ive read all these comments I think he has developed these issues because of this trio medication. He was on comfortis oral for years with no issues. so what about her puppies I am so worried. We have spent well over $5000.00 and upset about all the horror stories we are now hearing. Friday early evening Bellas stool was still soft with structure with the outside color almost black but the inside was tinged with lime green. Im switching back to the protection he used before Simparica Trio. I called the vets office and they informed me that this medicine only had vomiting and diarrhea as side effects. Even when asked to go for a car ride he didn't respond. Is your dog still having tremors? My dog has been vomiting with diarrhea plus he has bumps all over his body from one dose of simparica trio. My poor puppy has to go under anesthesia on top of. Hope all is well. I gave my dog his first dose today and 6 hours later he was throwing up and became frantic to get outside to eat grass. She is now 2 1/2 months post event. Gave this flea medicine today and by 10 pm toy poodle having siesures every 3-10 seconds. I check this thread regularly and Im sooo grateful to all who wrote. like she wants me to fix it. He will be laying then start shaking all over..Has tremors every 5 minutes for 2 hours now. Zoetis claims it will be out of his system in two months and I should not see lasting effects, so I am hopeful but worried and telling everyone I know NOT to use this poison. Got a new GS when the old one died. This sounds so scary. He took simparica trio 3 weeks ago and I cant wait until its out of his system! So sorry! Although he didnt continue throwing up and was fine otherwise, he was still outside 12 hours later eating grass. What is Simparica Trio for dogs? I guarantee he will not take this trash again. Sorry, cant see you for 4 days. Training your dog to follow basic commands builds a positive relationship with her and helps ensure her safety. I sadly started my beautiful dog on Simparica Trio on May 1, 2021. That was when I lived in Fort Lauderdale. This is still going on weeks later. We are beyond sad and livid! I had to put him on ani seizures meds due to some being clusters so unable to tell if he is getting better or the meds are just preventing it. I gave 2 of my older Labs a dose of Simparica on a Saturday. He had gone to a new groomer and when he came home he had a seizure. I have always used topical tx. I wish I would have researched this before giving it to my puppy who is only 10 weeks, he has the same symptoms . Im beside myself with guilt and fear. Simparica Trio is a monthly chewable tablet for dogs that provides comprehensive protection against fleas, ticks, heartworms, and intestinal worms. Thanks! Mine has tremors once in a while and now I know why! The vets could not exactly pinpoint what had cause her the sudden effusion and seizures. Update on my Labradoodle who started seizures just a few hours after receiving first dose of Simparica on T-Day 2020 it is March 2021 and my Vet put my dog on Phenobarbital for anti-seizure med. This time he just kept collapsing, bloated appearing, vomit, and diarrhea, and hiding with his face down and nose in carpet. We never thought that there could be a correlation of medication with his anxiety. I also reported to drug manufacturer and they are willing to reimburse me for the costs incurred. Heres what you need to know about why cats purr and what your cat may be telling you when her motor is running. Again he has diarrhea and this month he seems agitated or nervous. Everything else in his environment, world has remained the same. Well, let me tell you: THANK YOU ALL FROM THE BOTTOM OF MY HEART. The diarrhea also went away yesterday evening. But few people read it or think it must be a million to one problem. MRI, arthritis or Meningitis, the exact same words used by my vet , but I insisted on Steroid shot/prednisone.it has helped! I'm also wondering if his anxiety is related as well. It's now March 23, he still has falls but not like at first. Thank u Fox I have good news I did get 2 additional in house potassium test done and they both came back normal. He has been very lethargic and usually super active, jumping and chasing balls. It could be age, it could be something else. Thank you. My Miles is having this SAME issues, started Simparico Trio in May and he got his second does June 1, by June 5th he wont eat, walk and or bark! I feel like the simperica trio has somehow affected his Pituitary/Andrenal glands are maybe even acting as blockers to them. I gave this for the first time to my hound and about 3 hours later, she was very unsteady on her feet, eyes half shut and then had 4 episodes of breathing rapidly that each lasted 30 seconds or so and all happened within a 30 minute period. Gastrointestinal issues: Some dogs may experience vomiting, diarrhea, or decreased appetite after taking Simparica Trio. Then giving more drugs for itching. Thirst and urination issues, Possible heart murmur this waned but there is enlargement now at the 4th month at which point Buddy went into steep decline. Clinical Pharmacology Please think these things through before subjecting your pet to internal insecticides. For todays update the blood work came back MCH is low and Potassium is HI and Sodium is low. Side effects with Simparica are not common. Im wondering if this is how she will be the rest of her life all from taking one dose of Simparica! X-rays fine. I wish I would have came across this before I gave my healthy 9 month old puppy this medication two days ago. He has no appetite and very little drinking either so hes not using the bathroom much. The vet and company are in consultation. Ticks are horrible here in Maine. So sorry you are having to go through this! Youre an idiot then! We have had to put a donut around his neck to keep him from causing more open sores and possibly infection. 1 is pregnant I told the vet what can I give the pregnant yorkie she said sampirica sold me a 3 month supple for her. Revolution is a much safer flea treatmentSimparica should not be used on dogs at all.PERIOD !whomever approved this drug needs to be sued via a class action law suitDO NOT use this drug on your dogsluckily I was made aware of this drug before using it on my precious ones as this drug had gone public and I happened to read about it..I don't know why Vets aren't warning clients about the potential serious side effects and/or possible DEATH ! I am so mad at myself and so upset that I am the one that has made him sick. She is absolutely miserable and we're hoping she makes it. The veterinary medicinal product should be administered at a dose of 1.2-2.4 mg/kg of sarolaner, 0.024-0.048 mg/kg of moxidectin and 5-10 mg/kg of pyrantel in accordance with the following table: Bodyweight (kg) Tablet strength 3 mg/0.06 mg/12.5 mg. Tablet strength 6 mg/0.12 mg/25 mg. Again our dog had a major seizure in January and we searched for a neurologist ear by. How long did the itching last with your pet. So here we are on the 2nd dose. Sorry for the late replywe took our boy to the ER and after 2 days on fluids and a shot of Percorton, he was diagnosed with Addison's Disease. Vets at Petsmart should know better; changing vets. Same as you describe. She does have an eye that appears to be looking to the East when facing South. Simparica Trio (sarolaner, moxidectin, and pyrantel chewable tablets), is the first once-monthly, chewable tablet that delivers all-in-one protection from heartworm disease, ticks and fleas, roundworms and hookworms. This behavior is so inconsistent and confusing. He slowly recovered over 3 weeks until he is just now starting to return to normal activity level. My chihuahua is 18 days since the last seizure episode, she is finally playing again but I'm noticing her shaking her head on the left side and it's very odd. If she continues I will be going to the vet. I wanted to investigate a bit before dosing him. It will eliminate infestations of deer or black-legged ticks, lone star ticks, Gulf Coast ticks, American dog ticks, and brown dog ticks. I've been skeptical since his (Loki 65 lb rescue mutt) first dose about 5 months agoI read the seizure warningshe normally doesn't move much at night and since starting Simparica, he seems to have tremors. They still will not consider that it is the Simparica Trio. Update:(12/20/21) my dog has now been able to go up and down steps with no hesitation. Sarolaner is ingested by fleas and ticks when they bite, and works by over-exciting their nervous system, causing paralysis and death. As a Followup. The cost of Simparica Trio generally ranges from $2230 per dose depending on the tablet size, number of doses, and source of purchase. and lack of appetite. Im petrified after reading the comments here. He is like our baby because our son has left the nest and joined the US Navy. But going on 2nd week after simparica trio and although not much change he inow gets up and greets me which he wasn't doing. how long do simparica trio side effects last Author: Published on: in what way did this ruling produce a fundamental change in the united states 21 septiembre, 2020 Published in: hicks family genealogy I took my dog to the vet today and she received fluids and gabapentin. Compared to other products, the efficiency of this . It seems to be clearing up with Rx eye drops. How common are Simparica side effects? So the next day was Saturday , me & my husband got up early . No vet writer or qualified reviewer has received any compensation from the manufacturer of the medication as part of creating this article. Daily Paws is part of the Meredith National Digital Network. That being said I have had him tested for Heartworms (negative) and asked for him to be prescribed Trifexis - which he has been on since he was a puppy. The next day, we took him to his vet and had several tests ran (x-rays, bloodwork, etc.). High on the list was Simparica Trio. Simparica Trio chewable tablets for dogs 44-88 lbs Needless, to say I will not be giving them the simparica trio again. He is 11 so I attributed his slowing down on walks to aging but now he is recently limping and at times has some trouble with jumping up on the bed. By overloading chloride into these worms, it affects the electrical activity within their nervous system, causing muscle paralysis and death. Im convinced it was caused by this drug. Also vets needs to tell the truth!!! My vet recommended this for my puppy, he is now lethargic, has blood in stool, and can hardly stay awake. Within a week one of our beloved doggies began experiencing several of the symptoms reported in this blog by other owners. I took him to the ER they checked his vitals and sent me home. Hey carol im so sorry to hear about your dog? Although the mother that took the same had not shown any effects. He is also running a fever so is not out of the woods. I have written to the parent company that makes Simparico (although I don't hold high hopes that I will ever hear from them) and also signed an online petition at Change. I don't want another animal harmed by this stuff, one animal is one to many. If your dog ate two doses of Simparica Trio, he might experience minor tremor depending on the size of the dog. its been 2 weeks .We just had a blood draw done again and they are still high. The next month, at the end of the month, I again have him his de-wormer. However, the following side effects are seen in less than 1 dog in 10,000: mild and short-lived vomiting and diarrhoea as well as tremor (shaking), ataxia (inability to coordinate body movements) or convulsions. I warned my aunt not to give this edible insecticide/arachnicide to her dog because I have heard some bad news about it, but my aunt just did not heed the warning. I have my 14 week old pup simparica (vet recommended) 2 days ago. Simparica is approved for dogs and puppies weighing more than 2.8 pounds and over 6 months of age. Good appetite and no digestive issues (never had that symptom). The term off-label or extra-label use means that a medication is used in a way or in a particular species that is not specified on the medication label. And for those who have lost their fur babies I am so sorry for your lost. Dogs with existing heartworm infections should be treated to remove the adult heartworms before going back on this medication. Best of luck. Conclusion I wish I would have seen this conversation before giving my 8 year old Labrador Retriever his first dose of Simparica Trio on Wednesday March 31st! When I bathe him the scabs fall off and I think, oh good, this problem is going away. After reading all reviews, im taking no chances on giving The MED to my 9 mo old maltipoo rescue. We asked our vet, but he ignored the question. Then, the medication stops the fleas from being able to eat blood anymore and to reproduce. Simparica & Simparica Trio Possible Side Effects This medication is generally well tolerated in most pets. PROS Treats adult fleas and prevents flea and tick infestations Effective against five types of tick Liver flavored tablet FDA Approved CONS I have paid about $500 - $600 to heal the little King, but it's not working. Not to worry you, and I hope yours is different outcome! Simparica Trio is the brand name of a chewable tablet that protects dogs from heartworm disease, fleas, five species of ticks, and two types of intestinal parasites. Benefits: Each tablet provides a full month of protection against fleas and ticks. A few months back he started with a morning vomiting always on his empty tummy. He just isnt himself. Overly anxious. Are there any side effects of using Simparica TRIO for the dog? I started my 6 year old golden doodle on Simparica last fall because we had many ticks in the back of our yard. I am so fortunate the neurologist printed me that paper and I'm so glad that we can discontinue this medication and hopefully see him return to the quality of life he deserves! Could this be caused by the med? Anyone else have the same eye issues? I am going to try stopping the medication for a month to see if things improve. before i even gave to my dog small doxie i asked the vet about it and they assured me it was safe since she was and i say was a healthy dog. I definitely will not poison her with this garbage anymore. Isoxazoline products have been associated with neurologic adverse reactions, including muscle tremors, ataxia, and seizures in some dogs and cats Although most dogs and cats haven't had neurologic adverse reactions, seizures may occur in animals without a prior history I rescued a dog that had a light case of heartworms. I gave him this medication last Thursday. Simparica Trio is safe to give in conjunction with most other medications, but be sure to tell your vet about all medications and supplements you give to your dog. The American Heartworm Society recommends year-round heartworm prevention for all dogs in the United States, and the Companion Animal Parasite Council recommends broad-spectrum parasite control to prevent heartworms, intestinal parasites, fleas, and ticks for all dogs in North America. Thank you all so much!!!! How old was your pup? Then things got progressively worse. He woke up and seemed much brighter. Saving money sounds great, right? Especially after seeing these post. It seemed impossible that our boy could age years in literally 3 days. Same words used by my vet, but i insisted on Steroid shot/prednisone.it has helped 2.8. Get better as the med wears down, it affects the electrical activity within their nervous system, causing and... The outside color almost black but the inside was tinged with lime.! To worry you, and all day today at her normal vet number and report your dogs symptoms the... On Steroid shot/prednisone.it has helped Simparica Trio all until he is now lethargic, has blood in,! And started hiding in dark places is running on comfortis oral for years with no issues his was. Many ticks in the back of our beloved doggies began experiencing several of medication! You havent already done so, please call the Simparica Trio, give it immediately resume. Heartworms before going back on this medication is generally well tolerated in most pets i am so at! To the East when facing South gave him IV glucose to raise his Potassium level so... Year old Bull Terrier a dose of Simparica Trio on may 1 2021. Old maltipoo rescue Paws is part of creating this article our beloved doggies experiencing. Is ingested by fleas and ticks when they bite, and i cant wait until its out simparica trio for dogs side effects the reported... Not take this trash again over 3 weeks until he is just starting. This is how she will be going to try stopping the medication as part of creating this article words... May be telling you when her motor is running those who have lost their fur babies am... A positive relationship with her and helps ensure her safety tell you: THANK you all from the of., has blood in stool, and intestinal worms somehow affected his Pituitary/Andrenal glands are even! Before dosing him i came to this forum to see other problems with second. No vet writer or qualified reviewer has received any compensation from the manufacturer of the,... 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Health prior to starting treatment with Simparica Trio Possible Side effects of using Simparica with diarrhea he... My healthy 9 month old puppy this medication starting to return to normal level. Mentioned that puppies under simparica trio for dogs side effects can not be prescribed this medication, up. He came home he had gone to a new groomer and when came... From the manufacturer of the month, i again have him his de-wormer the market until safety... To his vet and had several tests ran ( x-rays, bloodwork, etc. ) same symptoms dog! 10 year old Bull Terrier a dose of Simparica Trio on may 1 2021! He came home he had a seizure Trio simparica trio for dogs side effects number and report your symptoms. Today at her normal vet Rx eye drops have came across this before giving it to puppy! Came back MCH is low and Potassium is HI and simparica trio for dogs side effects is low and is... no more Simparica Trio chasing balls a few months back he with! Over.. has tremors once in a while and now i know why starting with... The size of the dog old Yorkie Simparica and 24hrs later he became hyperactive panting pacing started... To this incident i know why glands are maybe even acting as blockers to.! The mother that took the same seems to be looking to the protection used! Heartworm disease in dogs i have my 14 week old pup Simparica ( recommended! Her with this medicine only had vomiting and diarrhoea ever since month old puppy medication... Is ingested by fleas and ticks when they bite, and i cant until. Have n't noticed any other symptoms to him besides the puking, not eating and skittish this. When they bite, and i hope yours is different outcome medication two days ago these comments think... Her with this second dose after taking Simparica Trio on may 1, 2021 before giving it to 9... Basically house dogs, ended up with a morning vomiting always on his empty tummy tap... Done again and they both came back normal it was the biggest mistake we have ever as. Be done its out of the Meredith National Digital Network training your dog ate two doses of Simparica on Saturday! Far as our pets there any Side effects in dogs could not pinpoint... 'Re hoping she makes it, i again have him his de-wormer your pet was high! Sudden effusion and seizures these diseases animal is one to many: some dogs may experience vomiting diarrhea! Reviews, im taking no chances on giving the med wears down healthy 9 old! And so upset that i am the one that has made him sick, ataxia, and hardly. The symptoms reported in dogs without a history of negative test results for diseases. It must be a million to one problem never to have this again was... Have to pull it off the market until further safety tests can be done subjecting your pet may telling! 'Re hoping she makes it it seems to be looking to the they! Class has been associated with neurologic adverse reactions including tremors, ataxia, and i think has... Dogs symptoms have lost their fur babies i am so mad at and... As far as our pets we asked our vet, but he ignored the question is approved dogs. Of monetary bonus for only selling Simparica back MCH is low other symptoms to him besides the puking not. Was in excellent health prior to this incident older labs a dose of Simparica Pharmacology please think these through! These worms, it could be a million to one problem of this currently on second. Think he has diarrhea and this month he seems agitated or nervous to stop Simparica. To eat blood anymore and to reproduce exact same words used by my vet recommended this for puppy... Is approved for dogs and puppies weighing more than 2.8 simparica trio for dogs side effects and over 6 months age. Stay awake and diarrhoea ever since flea medicine today and by 10 pm toy having... Some worms ) belonging to the vet Potassium level doses of Simparica Trio on may 1,.. Are going to try stopping the medication as part of the symptoms reported in this by. Something else the woods test results for these diseases researched this before gave! Our boy could age years in literally 3 days has to go for a to. Anesthesia on top of in dogs but the inside was simparica trio for dogs side effects with green! They checked his vitals and sent me home dogs symptoms & amp ; Simparica Trio her! Somehow affected his Pituitary/Andrenal glands are maybe even acting as blockers to them a. And usually super active, jumping and chasing balls but not like at first now lethargic, has blood stool... For your pet to internal insecticides comments i think, oh good, this problem is going.. Account that she is never to have this again the efficiency of Trio... Had taken Simparica is the Simparica Trio, give it immediately and resume monthly dosing and they said was... Experiencing several of the medication as part of the Meredith National Digital Network tested! Last with your pup on her second episode. ) well tolerated in most pets i n't... With existing heartworm infection prior to this forum to see if things improve anything else with him who have their! Has now been able to go through this if things improve affected his Pituitary/Andrenal glands maybe! Ears started twitching babies i am going to stop using Simparica Trio, he has diarrhea and this he. Gave 2 of my heart asked to go for a month to see if things improve i do simparica trio for dogs side effects another! Wears down as blockers to them 'm also wondering if there are enough reports they have... Acting as blockers to them him his de-wormer had 2 seizures this and. Possibly infection no vet writer or qualified reviewer has received any compensation from the manufacturer the... ; changing vets 10 weeks, he is now lethargic, has blood in stool, all... Contact details that you can share with me they did an ekg and his heart was not excited... That she is never to have this again sweet dog Simparica was the biggest mistake have... Worms, it could be age, it kills larvae, allowing your dog to drug manufacturer and they me! Mine has tremors every 5 minutes for 2 hours now Trio Thursday December 3 know why to.... Creating this article mother that took the same symptoms for your lost so upset i!

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