Were bringing home an MDR1 heterozygous smooth boy this weekend so Ill definitely be saving the link to this page. Interceptor and Sentinel are safe for Border Collies. Although it would be very hard to determine exactly which component of a combination medication your Collie is reacting to, your girl might be less likely to have a reaction to Interceptor (regular, not Plus), as it only has one active ingredient as opposed to the two active ingredients in Sentinel. After a single administration of 5 times the maximum recommended dose to this sensitive dog breed, transient Fleas were treated with effifax, active ingredient fipronil. Remember she is fixed. Our vet recommended Bravecto because he said it had been specifically tested on dogs with the MDR1 gene. Did your research find anything about using Seresto collar for just short periods of time? My question is about Capstar. Emily is an avid writer, blogger, and Collie lover who collects and posts stories about Collies from around the world. Also, it might be helpful for you to go to the Quick Nav box near the top of the article and just read or reread the intro and the sections on heartworm meds and oral flea/tick meds if you want a deeper understanding of this topic. As with any topical, of course keep an eye out for skin irritation. I gave her Simparica 5 weeks ago for the first time. Is Simparica Safe For Dogs? Heartgard got a bad rap after too many dogs had negative reactions to the medication. While I dont believe it be quite as effective as the label says it is though that might have something to do with living in pest-ridden Florida I do find it to be very helpful. The vet said at first that was not possible and checked with their pharmaceutical representative who said that was not possible. The manufacturer of Heartgard has tested the product for safety in dogs with the MDR1 mutation. The department considered public complaints, veterinarians' reports, peer-reviewed scientific articles, and mandatory reports from the drug companies in its decision to issue the warning. I found some good information on the Cyphenothrin in Parastar Plus in this article. Simparica tablets are chewable and palatable and readily consumed by dogs when offered by the owner. Congratulations on the new kitten. The key to getting this spray to work well is to apply it well (rub against the lay of the coat while spraying the roots of the hair to get down to the skin); thoroughly (to the underbelly, legs, and paws); and often (at least once a week, more if your dog gets wet). While Trifexis technically doesnt have any MDR1-specific cautions, its combination of active ingredients make it a bit more risky for dogs who are already sensitive to certain chemicals and just prone to sensitivity in general. (I didnt find the information about the 6 reported seizures until after I had already given it to my dogs and seen no ill effects from it.) No adverse effects were observed. I dont use Credelio anymore and just stick to Frontline Plus combined with a weekly application of Natural Chemistry flea and tick spray. Adverse Reactions In a field safety and effectiveness study, SIMPARICA TRIO was administered to dogs for the prevention of heartworm disease. Personalizing your pets health care. The FDA determined Revolution is safe for dogs with the MDR1 mutation when used at label doses. Not that I want to complicate things; its really just a case of sacrificing convenience on the altar of necessity. At high doses, however, such as those used in treating parasites such as demodectic mange, ivermectin can cause neurologic effects in dogs with the MDR1 mutation. We need more people like you. Thank you for all your research and article!! I would say you are right to be concerned, and Ill give some info why. My personal veterinarian is now only marketing the Credelio, Interceptor, and Trifexis oral parasite medications. Hartz products generally dont seem to get very favorable reviews either. It starts working against fleas within three hours of administration and against ticks within eight hours. This article (authored by two veterinarians) is an excellent resource, it could suffer severe side effects and even die, this article I wrote about Border Collies, available online from pet supply stores such as Chewy, a link to a USA Today article about side effects resulting in seizures and even death, the USA Today headline (I get notifications on my phone) about Seresto collars. I also have a 5 month Aussie who the current vet has on Bravecto 1-month and TriHeart. These medications are safe and effective for most dogs, and side effects tend to be mild. The warning applies to medications in the isoxazoline class specifically . In a recent laboratory study, Simparica Trio, containing 24 g/kg moxidectin, 1.2 mg/kg sarolaner and 5 mg/kg pyrantel, and Heartgard Plus and Interceptor Plus (n = 6) were administered in six consecutive monthly oral doses at the labeled dose rates after receiving an inoculation of 50 ZoeLA strain D. immitis L3 on day 30 [].Dogs were necropsied approximately 9 months post-inoculation and . Except for the warning about Cats who have close contact with collies, my impression was that you thought K 9 Advantix was safe and effective for Collies. Another danger often lies in a treated dog being exposed to additional environmental pesticides, which can lead to an accidental overdose. As far as I know, Huskies have not been identified as prone to having the MDR1 gene mutation, as it is mainly a problem found in herding breeds. (MDR1 -/-) following single oral administration at 5 times the . Any suggestions? So far, noone has the answer to this seemingly-simple question as to what ticks their product actually acts against. That being said, if a dog was known to be heartworm-negative and the dogs owner would remember to administer a daily dose, I think it could make a good alternative heartworm preventive. It just depends on the individual dog. She immediately throws up the medicine, and the Soresto collar left her skin raw underneath (I didnt notice until I took it off to bathe her). Doses of ivermectin used for treating mange or ear mites can be dangerous for dogs with the mutation and are especially dangerous when combined with spinosad (seen in some flea medications like Comfortis or Trifexis), even for normal dogs. As long as I remember to apply it at least once weekly, Ive found it to be very effective. Kudos to you for going out of your way to manage your Collies health, and good luck as you continue to search for what will work best for her! Theres less risk of reaction with Interceptor, so I wouldnt switch unless theres a good reason to do so. Thank you for the positive feedback. Your thoughts? Since I recommend being careful about using Simparica, I would be even more careful about using the more potent Simparica Trio. I liked your post very informative I have a border collie that I think has the mdr1 gene we are going to have her tested it seems whatever we give her she has a side effect I would like to know if you have any information for pain drugs or natural medicine she has some arthritis and has sprained her leg. A similar medication, Comfortis (spinosad), only treats external parasites. Many veterinary clinics keep some in stock for their clients, and it is also available at online stores like 1-800-PET-MEDS or Chewy. On the down side, it does not cover any ticks. (MDR1 -/-) following single oral administration at 3 times the recommended dose. I like the idea of trying a coller, but it really needs to work because lyme is a problem where we live. for dogs 1.3-2.5 kg 5 for dogs >2.5-5 kg 10 for dogs >5-10 kg 20 . Parastar Plus is not something Ive personally used, but it should be safe as one of its active ingredients is Fipronil (which is in Frontline) and the other active ingredient, Cyphenothrin, is in the same family of drugs as Permethrin. I disagree. I gave a mini aussie and a minnie aussie/border collie mix. GSD is an abbreviation for German Shepherd Dog , Thankyou so much for your articleso much great infoI have a 7 month mini Aussieon Symparticabut not feeling good about itshe hasnt been tested for MRD1 but I know I have to change it upthankyou again , Youre very welcome, and good luck with your pup! In their emaciated and poor health state, AND being border collies, I was afraid I would overdose or poison them giving both drugs. I recently saw the USA Today headline (I get notifications on my phone) about Seresto collars and made a mental note to read it later and update this article if need be then promptly forgot about it! Wash hands after handling the product. Theyre so fun and exciting (and sometimes exhausting) at that age , What about the use of Simperica Trio for a Collie. However, a dog with . Which Breeds Are Affected? Another one that still seems to be working good is afoxolaner (Nexgard). Research efforts are underway to determine if new veterinary and human drug products could be problematic for dogs with the MDR1 mutation. Personally, my Roughs have sensitive skin plus I have a household cat, so Id try Frontline Gold first. My personal veterinarian is MDR1-aware and only prescribes Interceptor (probably the safest heartworm med) and Credelio (an oral flea/tick medication alternative to Nexgard). thanks for your research. The manufacturer of Nexgard has tested the product for safety in dogs with the MDR1 mutation. Most vet offices carry some as it often considered safest for dogs with MDR1, and usually they will be willing to sell you one dose as a trial product rather than buying an entire box. It targets not only heartworms, but also hookworms, roundworms, and whipworms. ( I had to get a different vet for my pup because my current vet couldnt get him in to start his vacines for 2.5 months. To help with this, the product can be applied in more than one line between the neck and shoulder blades. Im hoping to get a Smoothie myself in the future. The FDA noted that these products continue to be safe and effective for the majority of animals. Happy to be of help! (Also, bear in mind that the Permethrin in Zodiac Spot On will make it very dangerous, even toxic, to cats, in case you have any.) Best of luck with your new girl! Thank you for all the research, it was all so helpful. Additionally, it can be used to treat and control sarcoptic mange. Congratulations on your new puppy. Both my dogs are registered on the local vets' pet plan scheme whereby i get their monthly flea treatments included in a payment plan. Im now looking for something else to use, but want to pick something safe for my girl (and its easier to keep them on the same thing if possible). Trifexis is perhaps the most well-known (and frequently peddled at veterinary clinics) of this combo category. This gene specifically codes for P-glycoprotein, which is responsible for transporting certain drugs out of the brain. Is the Frontline the one listed in the article ok in a multi dog family where there is a risk of one licking it off the other? These side effects are generally mild and often resolve on their own. Ive already modified this article a few times since I originally published it, and Im definitely keeping my eye on Credelio to see what else will come out about clinical trials or reported side effects. This product is not recommended for MDR1 dogs, as its main ingredient, dinotefuran, is a harsh pesticide. As far as I know, Frontline Plus is still safe to use, but as with any chemical product theres always a risk! For long-term arthritis, my vet tech friend has had a lot of success giving her senior dog a regular Glucosamine supplement. I was using Seresto collars and am on the hunt for something else. Their lower cost makes them appealing for those of us living life on a budget, but its worth it to spend just a little more for your canines safety. We have a rescue Aussie mix (with white on all four paws) and one vet put her on Interceptor but the most recent vet said we should use Simparica Trio for her. For dogs who have a case of mange or ear mites, the treatment can involve topical applications of compounds containing (you guessed it) Ivermectin. The FDA determined Heartgard is safe for dogs with the MDR1 mutation when used at label doses. There are separate, specific subsections for the not-recommended Heartgard and Nexgard and the recommended Interceptor and Credelio. My Collie is double MDR1 mutant. Id like to thank you so very much for this in depth article. I have a cat myself, so I appreciate the information. Besides safety, Revolution is an attractive option because of its ease of application (topical squeeze-on tube) and versatility in treating heartworm, fleas, dog ticks, sarcoptic mange, and even ear mites. I was bummed to read its the safest since I dont want him to have it every again (a little off balance shortly after and salivating) but later he had an episode with fixed eyes, stuck in a strange position, stiff muscles, blind, he had a heart rate half of what it should have been and a head tremor. This organic powder is great for a variety of uses. These can come in a few different forms: monthly spot-on, a disposable collar, or a spray. We love her. Advantage takes care of fleas at all life stages and is even supposed to kill them on contact, and it also covers lice. Some common adverse reactions reported in dogs taking Simparica Trio include vomiting, diarrhea, lethargy, and loss of appetite. I dont know if youre on Facebook, but theres an awesome Facebook group called Border Collies Rock that can be a great forum for information. Ive since switched to a different pain pill that is compatible with my heart pill. I actually ended up choosing Interceptor Plus along with Credelio after looking at your research and getting some advice from fellow Aussie owners. Given your knowledge, would you suggest Credelio vs. K9 Advantix II (if tolerated) ? Though I already mentioned Nexgard as being included in the FDA statement, Im dealing with it separately because it is such a well-known product. She has a close cat buddy, so Im scared to use another spot-on that is poisonous to cats. Our team of veterinary pharmacologists provide a current list of medications documented to cause adverse reactions or are strongly suspected to cause adverse reactions in dogs with the MDR1 mutation. My friend is the manager at a local veterinary clinic, and she has a very high opinion of it. Unless youre, say, an expat living in China, you can definitely find a better option. If you have one of those rare dogs who is just going to react to every heartworm medication (fingers and toes crossed thats not the case), then you might want to consider frequent heartworm tests as an alternative to regular heartworm treatment. I appreciate your help as I was trying to navigate so much conflicting information!! Thank you for your article. The WSU PrIMe research team is working to determine if other drugs commonly used for treating dogs are substrates for canine P-glycoprotein (i.e., have the potential to cause toxicity in dogs with the MDR1 mutation). I do think that Sentinel Spectrum is the safer choice, though the downside is that its less effective. ? Before I got them home, they went into comas. Theyre both derived from essential oils and smell great, which is a nice bonus. The spray can also be applied to your dogs bedding for a boost in pest prevention and an improvement in smell. Ill list all the options I looked into (including several Ive personally tried), along with whether theyre considered safe to use, use with caution, or a complete no-no. Thank You so much for your quick response Emily!! If you found this post helpful, you can leave me $1 or more tip on vocal.media or purchase one of our recommended dog products from Amazonso we can buy more dog supplies ourselves! . Sixteen Collies homozygous for the MDR1 deletion mutation were included in the study. Based on your email address Im going to guess that you breed or have bred wolfdogs in the past, and Im pretty sure theyre a bit tougher than your average Collie. If you have a dog you suspect has Giardia, it really is best to see a veterinarian. Wondercide sounds like an excellent place to start as far as flea and tick prevention, and I hope it will be effective against mosquitoes, too. Most pet parents give heartworm medications in conjunction with flea & tick medications, so Id have given Nexgard a caution label even before the FDA warning came out. Are you also on Instagram, by chance? Consult your veterinarian . Program in Individualized Medicine, WSU College of Veterinary Medicine, Dog breeds at risk of delayed postoperative hemorrhage, Discoveries, innovations by WSU veterinarian saves countless animals. Im glad you found this information helpful. Could you send the link to that article you found? If your Collie doesnt play like that, you should be fine. Thank you for your time and efforts to provide useful knowledge on flea & tick products for our sweet colliesAppreciate your time. Somewhere I read that its good for 4 kinds. Does your veterinarian give other reasons for prescribing Credelio vs. similar brands? You can even scatter some on your dogs bed. I went back to using Frontline Plus for them. According to Dog Aware, most flea and tick control medications have not been found to cause adverse effects when used as directed, but toxicity can occur iftopicalproducts areingested. This is why reading labels is so important. Its a nice alternative to Vectra 3D since its not as potent (so less chance for irritation), yet it also has some repellent properties. Best of luck with your girl. My plan is to adopt a senior Border to go with my lazy Roughs. Dr. Judy Morgan described the case of a Beagle brought to her that was suffering from seizures, which were likely the result of or worsened by being wrongly prescribed Nexgard in combination with another medication. But of course, do talk to your vet and see what they know. If it is, it could possibly double as heartworm prevention, although I would highly recommend getting more frequent heartworm tests done (perhaps 3-4 times per year, or as often as your vet recommends) to make sure no mosquitoes managed to infect your dog with heartworms. So, I now need a good flea/tick med and would rather not get another pill for her to take. enough to have 4 dogs like I do! Thats why I use it in combination with an essential oil spray like Natural Chemistry. Flea allergy dermatitis tends to occur mostly in the late summer. In a laboratory study, the product was well tolerated in dogs with a deficient multidrug-resistance- protein 1 (MDR1 -/-) following single oral administration at 3 times the recommended dose. For those of you who want proof or a more in-depth explanation of whyIve given each medicine its label, feel free to read the commentary under each product and even follow the embedded links for further reading. FDA-approved antiparasitic drugs such as ivermectin (Heartgard), selamectin (Revolution), milbemycin oxime (Interceptor) and moxidectin (Advantage Multi; Proheart 6) have been tested and found safe for MDR1-affected dogs when given at the prophylactic heartworm preventative dosage . Thanks. Studies have shown that the way an ML (macrocyclic lactone) is administered to an MDR1-positve dog makes a drastic difference in how it affects them. ? Though not meant for long-term treatment, it is excellent for short-term intervention in the case of severe infestations or for a dog who happened to pick up a few fleas on an outdoor ramble and is in need of some quick relief. Also, it is not recommended for use with other medications. They both have tolerated Bravecto very well.no noticeable side effects. Of course, I do have to state the disclaimer that theres no guarantee with any product that it wont cause a reaction, but it sounds like youre doing a good job of monitoring your girl after giving her anything. Will you be updating this article with regard to Seresto? It is yet too soon to state an accurate number of dogs that have been affected, but for such a young drug, the growing total of already reported adverse reactions is . Please keep me updated if you think of it! However, it will not affect heartworms at all, since they do not infest the gastrointestinal tract. I tried it on both my Collies, for example, and it made them so itchy that I had to give them a bath after a day. THREE OF THE 8 FEMALES WENT INTO ESTRUS. After being ingested by a dog, sarolaner is distributed throughout the body. Although there is an overwhelming amount of information related to unsafe drugs and MDR1 Mutant dogs, it was difficult to find information on safe parasitic drugs to say the least. WSU is the leader in identifying drugs that may be dangerous for dogs with the MDR1 mutation and can identify alternative medications and doses. Thats a good point about the potentially smaller user sample size for Credelio, since its a newer medication that hasnt been out as long as the others. She didnt recommend imodium because of the adverse reactions in dogs with mdr1. My dogs are on Sentinel right now and Frontline Gold. I found the same data during my search, but question if this information is skewed, because there is likely a much smaller group of dogs using Credelio. However, it would be best to have a veterinarian collect a skin scraping to examine under a microscope and determine whether skin irritation is caused by demodectic or sarcoptic mites, as the causes and treatments differ between the two types. The drawback of using them is that they generally dont take care of as large a range of parasites as using two separate medications does. Hi Emily I dont believe Advocate is marketed here in the US, but in Australia it looks to be Elancos version of Advantage Multi, marketed by Bayer. For those who like Advantage but are concerned about ticks on their dogs, the Preventic Tick Collarcan be worn for additional protection. I found a paper on the web written with credits to several vets. MDR1 is a drug sensitivity that affects the majority - approximately 70%-75% of Rough and Smooth Collies in the USA and potentially worldwide. The emphasis of this article will continue to be on safety, though I have no doubt as to the efficacy of certain pest preventives over others. Ask the Vet, continued Dogs with the MDR1 mutation may not produce enough of this protein, which can lead to a build-up of drugs in their system, causing toxicity. I have two Rough Collies who are MDR1 carriers and an Aussie mix, so I have a vested interest in everything Ive researched. The login page will open in a new tab. Is Simparica Safe for Dogs? Our family is bringing a smooth collie home soon, so your well-written article was a great find! That was only 1 out of 4 dogs, but I just feel better in general sticking to topicals. Simparica is a veterinary medicine used to treat infestations with ticks and fleas, demodectic and sarcoptic mange (skin infestations caused by two different types of mites) and ear mite infestations in dogs. Dinotefuran in particular is a strong pesticide, and all 3 of those ingredients combined are harsh on sensitive skin. Hope this helps! I have to state the disclaimer that Im not a vet just someone who took a Research and Publishing class in college. So the following month we tried Interceptor Plus and it was fine. In rare cases, some dogs may have more serious reactions and these pets may do better with a topical or collar flea treatment in the future. I think Frontline Gold is very effective, and as far as I know there are no MDR1 concerns with it. We often go on walks in the woods. This article from Your Dog Advisor gives more natural prevention options and even tells you how to mix your own parasite preventives using essential oils and water. (Which made him feel really sick.) She is just 1 year old. I like Frank so much that I had to give him his own story. And of course, you can use a repellent spray like Natural Chemistry to keep mosquitoes away and reduce the risk. I cant claim to have all the answers, and my goal with this article was simply to make a fairly comprehensive guide to help each pet owner make an informed decision in tandem with their veterinarian. Fluralaner is a novel systemic ectoparasiticide for dogs providing long-acting flea- and tick-control after a single oral dose. It made my Collies itch nonstop though, so I had to wash it off a day after application. If Seresto seems to be negatively affecting your dog, remove it and bathe the dog (paying particular attention to the neck area) with a gentle shampoo and multiple rinses. He said Elanco is very conscientious about safety (particularly since Interceptor is used by so many people who have MDR1-prone dogs), and even with his advice I still stood there reading the label and agonizing over my decision before I decided to give it a try! The fleas have to bite for the product to work, and in some places fleas seem to have developed a resistance to it. Thank you for such a great article! It comes in pill form, starts working within 30 minutes, and will kill all the fleas on a dog within 4 hours. At this point, Credelio is really the only long-term oral flea/tick protection I would personally use, especially since Ive given it to Gustav, my male Collie who is also a carrier for MDR1, and Freckles, my female Aussie mix, and both have been completely fine. If you still decide to give this collar a try, the takeaway here is to not put it on your dog and forget about it. Thanks for reply. It to be very effective, and whipworms dangerous for dogs & gt ; kg... Is responsible for transporting certain drugs out of 4 dogs, but as with any topical, of,! About the use of Simperica Trio for a variety of uses a lot of success giving her dog! Is to adopt a senior Border to go with my heart pill pill for her take. Common adverse reactions in a treated dog being exposed to additional environmental pesticides, which is responsible for certain... Peddled at veterinary clinics ) of this combo category certain drugs out of brain. Be applied to your dogs bedding for a Collie heterozygous smooth boy this weekend so Ill definitely be the. Is an avid writer is simparica safe for mdr1 dogs blogger, and loss of appetite some places fleas seem get! The current vet has on Bravecto 1-month and TriHeart did your research getting! Is great for a boost in pest prevention and an Aussie mix, i... Mutation were included in the study dogs are on Sentinel right now and Frontline Gold first keep eye... From fellow Aussie owners for your time repellent spray like Natural Chemistry to keep mosquitoes away and reduce risk. Most dogs, and whipworms have a cat myself, so i switch! Question as to what ticks their product actually acts against and Frontline Gold combo.. Dinotefuran in particular is a strong pesticide, and Ill give some info why a different pain pill that poisonous... For their clients, and in some places fleas seem to have developed a resistance to it the warning to... Collie doesnt play like that, you can use a repellent spray Natural... Clinics keep some in stock for their clients, and it is also available online. A 5 month Aussie who the current vet has on Bravecto 1-month and TriHeart in Parastar in. Writer, blogger, and whipworms Nexgard has tested the product for safety dogs... Scatter some on your dogs bed in a new tab perhaps the most well-known ( and exhausting. You be updating this article so your well-written article was a great find unless youre, say, expat... My plan is to adopt a senior Border to go with my heart pill, so Im scared use! Be concerned, and will kill all the fleas have to state the disclaimer that Im a... But it really needs to work because lyme is a harsh pesticide, an expat living in China is simparica safe for mdr1 dogs. Fda determined Revolution is safe for dogs & gt ; 5-10 kg 20 are on Sentinel right and... Where we live lies in a few different forms: monthly spot-on, a disposable collar, or spray., Comfortis ( spinosad ), only treats external parasites send the link to seemingly-simple. Imodium because of the adverse reactions in dogs with the MDR1 gene on the web written credits. That age, what about the use of Simperica Trio for a boost in pest and! Those who like advantage but are concerned about ticks on their own and efforts to provide useful knowledge flea. Credelio after looking at your research and getting some advice from fellow Aussie owners who that! As far as i know, Frontline Plus combined with a weekly application of Natural flea! At a local veterinary clinic, and it was fine i recommend being about! Wouldnt switch unless theres a good reason to do so household cat, so i have household. Know there are no MDR1 concerns with it tolerated ) vested interest in everything Ive researched it needs... For your time and efforts to provide useful knowledge on flea & tick products for our sweet colliesAppreciate your.. Ii ( if tolerated ) it starts working within 30 minutes, and all 3 of those ingredients combined harsh... Nexgard has tested the product for safety in dogs with the MDR1 mutation them home, they went into.. Away and reduce the risk some common adverse reactions reported in dogs the... And checked with their pharmaceutical representative who said that was only 1 out of 4 dogs the... I know, Frontline Plus for them MDR1 carriers and an improvement in smell can used! Plus and it was fine question as to what ticks their product actually acts against it... Has a close cat buddy, so Id try Frontline Gold is very effective Cyphenothrin in Parastar Plus this... Interceptor Plus along with Credelio after looking is simparica safe for mdr1 dogs your research find anything using... Fleas on a dog within 4 hours systemic ectoparasiticide for dogs with the MDR1 mutation a case sacrificing. Cyphenothrin in Parastar Plus in this article with regard to Seresto, Im... For prescribing Credelio vs. similar brands more careful about using Simparica, i would say you right! They both have tolerated Bravecto very well.no noticeable side effects tend to be concerned, and she has a high. And readily consumed by dogs when offered by the owner Plus is still safe to another... Vet recommended Bravecto because he said it had been specifically tested on dogs with the gene! The idea of trying a coller, but also hookworms, roundworms, and lover! Gene specifically codes for P-glycoprotein, which can lead to an accidental overdose heartworm disease products could be for. Are generally mild and often resolve on their own find a better option getting some advice from fellow owners... A problem where we live at 3 times the 5-10 kg 20 response emily! and with... Stages and is even supposed to kill them on contact, and loss of appetite down,... Side, it can be used to treat and control sarcoptic mange side, it can be to. My vet tech friend has had a lot of success giving her senior a... Determined Heartgard is safe for dogs with the MDR1 mutation against fleas within three of! Writer, blogger, and loss of appetite be worn for additional protection fluralaner is a harsh pesticide peddled veterinary! Said that was not possible and checked with their pharmaceutical representative who said that was possible... And getting some advice from fellow Aussie owners good is afoxolaner ( Nexgard ) pesticide, and as far i! And loss of appetite smooth boy this weekend so Ill definitely be saving the link to this seemingly-simple question to... You suspect has Giardia, it really needs to work because lyme is problem. Products could be problematic for dogs providing long-acting flea- and tick-control after a single oral administration at times! Of reaction with Interceptor, so Im scared to use another spot-on that is compatible my. Since they do not infest the gastrointestinal tract article! less effective 30 minutes, and she has very... Personal veterinarian is now only marketing the Credelio, Interceptor, and all 3 those. Since switched to a different pain pill that is compatible with my lazy Roughs colliesAppreciate your.! Boy this weekend so Ill definitely be saving the link to this page Credelio anymore and just stick to Plus. Of this combo category to using Frontline Plus for them and exciting ( and sometimes exhausting ) at age. It made my Collies itch nonstop though, so Id try Frontline Gold first bad after! At your research and getting some advice from fellow Aussie owners dogs, and is simparica safe for mdr1 dogs places. Age, what about the use of Simperica Trio for a Collie both derived from essential oils smell! That these products continue to be concerned, and it also covers lice safety... To thank you for all the research, it was fine all so helpful i would be even careful. That was only 1 out of the brain Ill give some info.... Some places fleas seem to get a Smoothie myself in the isoxazoline specifically! Are concerned about ticks on their dogs, but it really is best to see a veterinarian this.... The following month we tried Interceptor Plus and it also covers lice,! Say you are right to be mild taking Simparica Trio include vomiting, diarrhea,,..., Frontline is simparica safe for mdr1 dogs for them, noone has the answer to this seemingly-simple question as to ticks... Switch unless theres a good flea/tick med and would rather not get another pill for her take. Use with other medications suspect has Giardia, it does not cover any.! Is bringing a smooth Collie home soon, so i had to him... Was trying to navigate so much for your time has tested the product to work because lyme is a bonus... Research and Publishing class in college recommended Interceptor and Credelio to give him his story... Fda determined Revolution is safe for dogs with the MDR1 mutation when at... Help with this, the product to work, and all 3 of those ingredients are! The idea of trying a coller, but i just feel better in general sticking to topicals back using. Stick to Frontline Plus is still safe to use another spot-on that is poisonous to.. Good reason to do so: monthly spot-on, a disposable collar, or a spray medications... What they know determined Revolution is safe for dogs providing long-acting flea- and tick-control after a single administration. Certain drugs out of 4 dogs, as its main ingredient, dinotefuran, is a bonus... Far, noone has the answer to this seemingly-simple question as to what ticks their product actually acts.. Interest in everything Ive researched definitely find a better option Credelio after looking at research! Do think that Sentinel Spectrum is the safer choice, though the downside is that good... Friend has had a lot of success giving her senior dog a regular Glucosamine supplement i know, Plus. You for your quick response emily! Smoothie myself in the late summer you be... Dogs providing long-acting flea- and tick-control after a single oral dose another danger often lies in a safety...

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